How do meningococcal toxins cause necrosis?

When meningococcal bacteria enter the bloodstream, they release potent endotoxins. These endotoxins are the primary cause of dangerous chain reactions within the body. They activate a series of systemic inflammatory responses, causing severe damage to cells and tissues. Simultaneously, the toxins also induce severe blood clotting disorders, obstructing small blood vessels and impeding the supply of blood and oxygen to the limbs and organs. The consequence of these inflammatory reactions and blood clotting disorders is limb necrosis, a condition where tissue dies due to ischemia. Furthermore, this severe functional disruption can lead to multi-organ failure, directly threatening the patient's life if not treated promptly.

Key points
* Meningococcus releases endotoxins upon entering the blood.
* Toxins activate inflammation and blood clotting disorders.
* Leads to limb necrosis and multi-organ failure.

Nguồn / Source: VnExpress - Sức khỏe